Aniline → HCID 67044954, compound

HRID 1023696Notes

Reaction equation

HRID 1023696 reaction equation
C(O[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11]Br)C.[CH2:14]([O:16][C:17](=[O:27])[CH:18]=[CH:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1)[CH3:15].NC1C=CC=CC=1>>[CH2:14]([O:16][C:17](=[O:27])[CH:18]=[CH:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:11][C:6]3[C:5](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:4]2=[O:13])=[CH:24][CH:25]=1)[CH3:15]

Participants

4

Reactant 3

HCID 6115AnilineHCID 97826Ethyl 3-(4-aminophenyl)acrylateHCID 11032082Ethyl 2-(bromomethyl)benzoate

Product 1

HCID 67044954HCID 67044954, compound

Procedure

By using 2-bromomethyl-benzoic acid ethyl ester and 4-aminocinnamic acid ethyl ester instead of 2-bromomethyl-6-nitro-benzoic acid methyl ester and aniline used in Example 25, synthesis was performed in the same manner as that of Example 25 to obtain 3-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-acrylic acid ethyl ester (Compound 23) as white crystals.

Workup

  1. customused in Example 25, synthesis

Sources & evidence

ORD record
ord-994af41354be4ed28419050fee21136e
Source dataset
uspto-grants-2014_05
Patent number
US08722723B2

Reaction notes

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