Aniline → HCID 67044950, compound

HRID 1023697Notes

Reaction equation

HRID 1023697 reaction equation
C(O[C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[CH2:14]Br)C.[CH3:17][O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([NH2:28])=[CH:24][CH:23]=1.NC1C=CC=CC=1>>[CH3:17][O:18][C:19](=[O:29])[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([N:28]2[CH2:14][C:6]3[C:5](=[CH:10][C:9]([N+:11]([O-:13])=[O:12])=[CH:8][CH:7]=3)[C:4]2=[O:16])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 6115AnilineHCID 6422115Methyl(4-aminophenoxy)acetateHCID 18510925HCID 18510925, compound

Product 1

HCID 67044950HCID 67044950, compound

Procedure

By using 2-bromomethyl-5-nitrobenzoic acid ethyl ester and (4-amino-phenoxy)-acetic acid methyl ester instead of 2-bromomethyl-6-nitro-benzoic acid methyl ester and aniline used in Example 25, synthesis was performed in the same manner as that of Example 25 to obtain [4-(6-nitro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenoxy]-acetic acid methyl ester (Compound 25) as a yellow green powdery substance.

Workup

  1. customused in Example 25, synthesis

Sources & evidence

ORD record
ord-3dbc2a63a7c1495d92b1486693fcab34
Source dataset
uspto-grants-2014_05
Patent number
US08722723B2

Reaction notes

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