HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 4-[4-(6-Fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Ethyl 4-(4-aminophenyl)butanoate | HCID 10013251 | — |
| Reactant | Ethyl 2-(bromomethyl)-5-fluorobenzoate | HCID 14626277 | — |
| Product | 4-[4-(6-Fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid ethyl ester | HCID 67045731 | — |
Reaction Steps
By using 2-bromomethyl-5-fluorobenzoic acid ethyl ester and 4-(4-amino-phenyl)butyric acid ethyl ester instead of 2-bromomethyl-6-nitro-benzoic acid methyl ester and aniline used in Example 25, synthesis was performed in the same manner as that of Example 25 to obtain 4-[4-(6-fluoro-1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid ethyl ester as an orange oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722723B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c3db96fe9c2b4812b787610d9d99e177 |
| Source note | uspto-grants-2014_05 |