Methyl 4-aminobenzoate → HCID 25189526, compound

Participants

Reaction Steps

A solution of 4,5-diisopropylpyrrole-2-carboxylic acid (78 mg, 0.400 mmol) and methyl 4-aminobenzoate (181 mg, 1.20 mmol) in dichloromethane (5 ml) was added with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (192 mg, 1.00 mmol) under an argon atmosphere, and the mixture was stirred at room temperature for 2 hours. The reaction mixture was treated in a conventional manner, and then the resultant was purified by silica gel chromatography (0.5% methanol-chloroform) to obtain the desired condensate (27 mg, 21%) from the low polarity portion, and the acid anhydride (30 mg, 40%), the starting material, from the high polarity portion.

Provenance & Evidence