HCID 67395110, compound → HCID 25189597, compound

HRID 1023722Notes

Reaction equation

HRID 1023722 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[O:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:22])[CH3:21])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5]>[OH-].[Na+]>[Cl:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[O:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:21])[CH3:22])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 67395110HCID 67395110, compound

Product 1

HCID 25189597HCID 25189597, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The aforementioned ester (102 mg, 0.280 mmol) was hydrolyzed with sodium hydroxide in a conventional manner, and extraction and recrystallization were performed to obtain the title compound (23, 88 mg, 90%) as pale yellow needles.

Sources & evidence

ORD record
ord-1603af51a419458f814e1ca4002e6b26
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

Loading…