HCID 67395294, compound → HCID 67395325, compound

HRID 1023736Notes

Reaction equation

HRID 1023736 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:22])[CH3:21])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=[O:5]>[OH-].[Na+]>[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:21])[CH3:22])[CH:19]=2)=[O:14])[CH:9]=[CH:8][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 67395294HCID 67395294, compound

Product 1

HCID 67395325HCID 67395325, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The aforementioned ester (42 mg, 0.116 mmol) was hydrolyzed with sodium hydroxide in a conventional manner, and extraction and recrystallization were performed to obtain the title compound (39, 34 mg, 83%) as colorless prisms.

Sources & evidence

ORD record
ord-009528c5a174498abd2a8c692b62a662
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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