Benzoic acid, 4-amino-2,6-difluoro-, ethyl ester (9CI) → HCID 67394321, compound

Participants

Reaction Steps

In the same manner as that of Example 24, 4,5-diisopropylthiophene-2-carboxylic acid (80 mg, 0.377 mmol) and ethyl 2,6-difluoro-4-aminobenzoate (137 mg, 0.681 mmol) were condensed, the reaction mixture was treated in a conventional manner, and then the residue was purified by silica gel chromatography [n-hexane-ethyl acetate (40:1)] to obtain methyl 2,6-difluoro-4-[(4,5-diisopropylthiophene-2-carbonyl)amino]benzoate (88 mg, 59%).

Provenance & Evidence