HCID 67394321, compound → HCID 67397258, compound

HRID 1023744Notes

Reaction equation

HRID 1023744 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:22])[CH3:21])[CH:19]=2)=[O:14])[CH:9]=[C:8]([F:26])[C:3]=1[C:4]([O:6]C)=[O:5]>[OH-].[Na+]>[F:26][C:8]1[CH:9]=[C:10]([NH:12][C:13]([C:15]2[S:16][C:17]([CH:23]([CH3:25])[CH3:24])=[C:18]([CH:20]([CH3:21])[CH3:22])[CH:19]=2)=[O:14])[CH:11]=[C:2]([F:1])[C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 67394321HCID 67394321, compound

Product 1

HCID 67397258HCID 67397258, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

The aforementioned ester (83 mg, 0.209 mmol) was hydrolyzed with sodium hydroxide in a conventional manner, and extraction and recrystallization were performed to obtain the title compound (43, 66 mg, 86%) as colorless prisms.

Sources & evidence

ORD record
ord-cc3595df5c1d4f4f8b385f9f43460d99
Source dataset
uspto-grants-2014_05
Patent number
US08722730B2

Reaction notes

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