Boron tribromide → HCID 67277099, compound

HRID 1023777Notes

Reaction equation

HRID 1023777 reaction equation
B(Br)(Br)Br.[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([O:31]CC2C=CC=CC=2)=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)(=[O:20])=[O:19])=[C:14]([C:27]([F:30])([F:29])[F:28])[CH:13]=2)[CH:11]=1>C(Cl)Cl>[Cl:5][C:6]1[CH:7]=[CH:8][C:9]([OH:31])=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)(=[O:20])=[O:19])=[C:14]([C:27]([F:28])([F:29])[F:30])[CH:13]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 131728176HCID 131728176, compound

Product 1

HCID 67277099HCID 67277099, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Boron tribromide (2.5 ml, 1.0 M in DCM) was added to a solution of the product from step b) (1.16 g) in DCM (15 ml) at 0° C. The solution was stirred for 15 min then quenched with water. The mixture was extracted with DCM (three times), the organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound (851 mg).

Workup

  1. customthen quenched with water
  2. extractionThe mixture was extracted with DCM (three times)
  3. dry with materialthe organic extracts were dried (MgSO4)
  4. customevaporated
  5. custompurified by chromatography (silica, petrol-ether as eluent)

Sources & evidence

ORD record
ord-0e884cb3f40c41e8861c14ca1c0d0db2
Source dataset
uspto-grants-2014_05
Patent number
US08722741B2

Reaction notes

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