Pyridine → N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,4-difluorobenzenesulfonamide

HRID 102379Notes

Reaction equation

HRID 102379 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH2:21])[cH:22]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[Cl:42][CH2:43][Cl:44].[F:30][c:31]1[c:32]([S:38](=[O:39])(=[O:40])[Cl:41])[cH:33][cH:34][c:35]([F:37])[cH:36]1.[cH:24]1[cH:25][cH:26][n:27][cH:28][cH:29]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:23])[c:20]([NH:21][S:38]([c:32]4[c:31]([F:30])[cH:36][c:35]([F:37])[cH:34][cH:33]4)(=[O:39])=[O:40])[cH:22]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27342732,4-Difluorobenzenesulfonyl ChlorideHCID 579897855-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluoroaniline

Product 1

HCID 57989690N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,4-difluorobenzenesulfonamide

Sources & evidence

ORD record
ord-ce272d84eae6406093da297cef4e6b40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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