HCID 67409514, compound → HCID 67407072, compound

HRID 1023832Notes

Reaction equation

HRID 1023832 reaction equation
[CH3:1][NH:2][C:3]1[NH:7][N:6]=[N:5][N:4]=1.[NH2:8][C:9]([CH3:50])([CH:47]([CH3:49])[CH3:48])[CH2:10][O:11][C@@H:12]1[C@@:19]2([CH3:44])[C@@H:20]3[CH2:21][CH2:22][C@H:23]4[C:32]([C@@:15]3([CH2:16][O:17][CH2:18]2)[CH2:14][C@H:13]1OC)=[CH:31][CH2:30][C@:29]1([CH3:33])[C@:24]4([CH3:43])[CH2:25][CH2:26][C@@:27]([C@H:38]([CH3:42])[CH:39]([CH3:41])[CH3:40])([CH3:37])[C@H:28]1[C:34]([OH:36])=[O:35]>>[NH2:8][C:9]([CH3:50])([CH:47]([CH3:49])[CH3:48])[CH2:10][O:11][C@@H:12]1[C@@:19]2([CH3:44])[C@@H:20]3[CH2:21][CH2:22][C@H:23]4[C:32]([C@@:15]3([CH2:16][O:17][CH2:18]2)[CH2:14][C@H:13]1[N:5]1[N:6]=[N:7][C:3]([NH:2][CH3:1])=[N:4]1)=[CH:31][CH2:30][C@:29]1([CH3:33])[C@:24]4([CH3:43])[CH2:25][CH2:26][C@@:27]([C@H:38]([CH3:42])[CH:39]([CH3:40])[CH3:41])([CH3:37])[C@H:28]1[C:34]([OH:36])=[O:35]

Participants

3

Reactant 2

HCID 67409514HCID 67409514, compoundHCID 178482507HCID 178482507, compound

Product 1

HCID 67407072HCID 67407072, compound

Procedure

Employing a procedure analogous that described in the preceding Examples, but using N-methyl-1H-tetrazol-5-amine, the title compound was prepared from (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-(2-amino-2,3-dimethylbutoxy)-8-[(1R)-1,2-dimethylpropyl]-14-methoxy-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid (prepared as described for Intermediate 6, but as a ˜1:1 mixture of diastereomers).

Workup

  1. customprepared
  2. additionas a ˜1:1 mixture of diastereomers)

Sources & evidence

ORD record
ord-3bcff057b2bc466d9f6cdb2baa30b009
Source dataset
uspto-grants-2014_05
Patent number
US08722727B2

Reaction notes

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