4-Piperidineethanol → HCID 67206122, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(piperidin-4-yl)ethanol (0.30 g, 2.32 mmol) in anhydrous dichloromethane (10 mL), NaHCO3 (0.59 g, 6.97 mmol) was added. The suspension was cooled to 0° C. and then 3,3-dimethylbutanoyl chloride (0.38 g, 2.79 mmol) was added dropwise over a period of 15 min. The reaction was followed by TLC till the disappearance of the starting material (overnight) and was then filtered. The residue was then purified using column chromatography on a silica gel column eluting with a solution of ethyl acetate in hexane (50%) to produce the alcohol in a 45% yield.

Provenance & Evidence