Ammonia → HCID 178524298, compound

Participants

Reaction Steps

To a solution of ethyl 2-(2-(2-(1H-imidazol-4-yl)phenoxy)acetyl)benzoate (0.142 mmol) in a mixture of tetrahydrofuran (2 mL) and water (1 mL) was added LiOH.H20 (0.713 mmol). After stirring for 5 h the reaction mixture was acidified with 6N HCl and treated with NH3 (solution in ethanol) till the pH was basic, the solution was concentrated under reduced pressure and subjected to column chromatography to afford the final product. Yield 46%. (CDCl3+CD3OD): 4.69 (s, 2H), 6.87 (d, 1H, J=6.18 Hz), 6.95 (t, 1H, J=5.55 Hz), 7.19 (t, 1H, J=5.79 Hz), 7.38 (d, 1H, J=5.10 Hz), 7.47-7.56 (m, 4H), 7.79 (d, 1H, J=5.00 Hz), 8.21 (br s, 1H).

Provenance & Evidence