Boron tribromide → HCID 52933448, compound

Participants

Reaction Steps

To a suspension of 5-(5-chloro-2,3-dimethoxyphenyl)-1H-imidazole (0.080 g, 0.335 mmol) in dichloromethane (4 mL) at −78° C. was added BBr3 (1.01 mmol) and the reaction mixture was allowed to warm to room temperature. After stirring overnight, the reaction was quenched by cautious addition of satd. NH4Cl solution (3 mL). The product was extracted with CH2Cl2 (3×10 mL), the combined organic extract was washed with water, brine and dried (MgSO4) and concentrated in vacuum to afford the crude product. The crude was passed through a short pad of silica gel to afford the final product. Yield 62%. 1H NMR: 6.82 (d, 1H, J=2.40 Hz), 6.99 (d, 1H, J=2.40 Hz), 7.34 (s, 1H), 7.75 (s, 1H)

Provenance & Evidence