Potassium Carbonate → 1-[4-(2-Hydroxyethyl)phenyl]-2-pyrrolidinone

Participants

Reaction Conditions

Reaction Steps

A mixture of CuI (0.198 mmol), N,N-dimethylethylamine (0.398 mmol), K2CO3 (3.98 mmol) and pyrrolidin-2-one (3.98 mmol) was purged with nitrogen gas. 2-(4-bromophenyl)ethanol (1.99 mmol) was added and the mixture was purged with purged again with nitrogen. The reaction mixture was stirred at 130° C. overnight. After cooling to room temperature, the reaction mixture was diluted with water (25 mL), NH4OH (5 mL) and the aqueous layer was extracted with dichloromethane (3×40 mL). The combined organic extracts were dried over sodium sulfate and evaporated under reduced pressure; the crude was purified by column chromatography to afford the final product. Yield=37%.

Provenance & Evidence