Boron tribromide → HCID 59191327, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-chloro-2-(2-methoxy-4-propyl phenoxy) pyridin-3-amine (0.1 mmol; 30 mg) under argon, in dichloromethane (2 mL), cooled to −78° C., was added BBr3 (0.5 mmol; 0.5 mL) dropwise. The reaction mixture was allowed to stir for 5 hr, with gradual warming to −20° C. At −20° C., the reaction was hydrolysed with saturated NH4Cl (4 mL), extracted with dichoromethane (3*10 mL). Combined organic phases dried over Na2SO4, concentrated in vacuo, to give the desired product as a light brown solid without further purification (27 mg 0.1 mmol; 97%).

Provenance & Evidence