2-[2-(Benzyloxy)-4-ethylphenoxy]-6-fluoropyridine → 5-Ethyl-2-[(6-fluoropyridin-2-yl)oxy]phenol

Participants

Reaction Steps

2-[2-(benzyloxy)-4-ethylphenoxy]-6-fluoropyridine (28 mg; 0.09 mmol) was dissolved in ethanol (4 mL), under argon. Palladium on charcoal (4 mg; 0.02 mmol) was added and the reaction was flushed twice with hydrogen, then left to stir overnight at room temperature. The reaction mixture was filtered on celite, then rinsed with methanol (3*3 mL). Concentration yielded a white solid (25 mg; 98%) of title compound.

Provenance & Evidence