HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 2-Fluoro-6-(4-{2-[(6-fluoropyridin-2-yl)oxy]ethyl}-2-methoxyphenoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Homovanillyl alcohol | HCID 16928 | — |
| Reactant | 2,6-Difluoropyridine | HCID 73934 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-6-(4-{2-[(6-fluoropyridin-2-yl)oxy]ethyl}-2-methoxyphenoxy)pyridine | HCID 24785926 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
To a suspension of KOH (2 mmol; 112 mg) in anhydrous DMF (1 mL) under argon, was added 4-(2-hydroxyethyl)-2-methoxyphenol (1 mmol; 168 mg) followed by 2,6-Difluoropyridine (1 mmol; 0.1 ml). The reaction mixture was stirred at 110° C. for 20 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722746B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-58e94e0e252246328a8e860ad3e54cbc |
| Source note | uspto-grants-2014_05 |