HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluoropyridine → 2-(4-Bromo-5-fluoro-2-methoxyphenoxy)-6-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluoropyridine | HCID 73934 | — |
| Reactant | 2-Fluoro-5-nitrobenzotrifluoride | HCID 94954 | — |
| Reactant | 4-Bromo-5-fluoro-2-methoxyphenol | HCID 26596525 | — |
| Product | 2-(4-Bromo-5-fluoro-2-methoxyphenoxy)-6-fluoropyridine | HCID 59191227 | — |
Reaction Steps
According to the procedure of example 20(a) except substituting 2-methoxy-4-propylphenol for 4-bromo-5-fluoro-2-methoxyphenol (441 mg; 2 mmol), and 1-fluoro-4-nitro-2-(trifluoromethyl)benzene for 2,6-Difluoropyridine (0.18 mL; 2 mmol), the title compound was prepared as a yellow oil (246 mg; 39%), after purification on silica gel (cyclohexane/ethyl acetate: 95/5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722746B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-45bc184a5bb34fe7a54b0d50537bd8a7 |
| Source note | uspto-grants-2014_05 |