Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Reactant | 5-(4-Methylpiperazin-1-yl)pyridin-2-amine | HCID 22329833 | — |
| Reactant | 8-Bromo-6-chloroimidazo(1,2-a)pyridine | HCID 26370038 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86684119 | HCID 86684119 | 44% |
Reaction Steps
A mixture of 101a (2.3 g, 10 mmol), 5-(4-methylpiperazin-1-yl)pyridin-2-amine (1.9 g, 10 mmol), XantPhos (576 mg, 1.0 mmol), Pd2(dba)3 (915 mg, 1.0 mmol) and Cs2CO3 (6.5 g, 20 mmol) in dioxane (50 mL) was heated at 100° C. for 12 h under nitrogen. It was then filtered and evaporated in vacuo. The residue was purified by silica-gel column eluting with 1:1 ethyl acetate/petroleum ether to afford 101b as a green solid (1.5 g, 44%). MS: (M+H)+ 343.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08722676B2 |
|---|
| Source dataset | uspto-grants-2014_05 |
|---|
| ORD ID | ord-f53bc8b6ef59464ea3ee84ac590c234d |
|---|
| Source note | uspto-grants-2014_05 |
|---|
