HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → HCID 86684122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 3-Oxetanone | HCID 15024254 | — |
| Reactant | 6-Chloro-N-(5-(piperazin-1-yl)pyridine-2-yl)imidazo[1,2-a]pyridin-8-amine | HCID 86684121 | — |
| Catalyst | ZINC;ethoxyethane;dichloride | HCID 162251561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86684122 | HCID 86684122 | 30% |
Reaction Steps
A mixture of 102b (0.773 g, 1.75 mmol), oxetan-3-one (0.189 g, 2.62 mmol), NaBH3CN (0.22 g, 3.5 mmol), and zinc chloride/Et2O (3.5 ml, 3.5 mmol) in methanol (40 mL) was stirred at 50˜60° C. for 5 hours. The solid was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography eluting with 5:1 CH2Cl2/methanol to afford 102c (200 mg, 30%). MS: [M+H]+ 385.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722676B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ec592ed5d04c4bfc95378f21248e8c6b |
| Source note | uspto-grants-2014_05 |