HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetaldehyde → 8-Bromo-6-chloroimidazo(1,2-b)pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 3-Amino-4-bromo-6-chloropyridazine | HCID 22024419 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Bromo-6-chloroimidazo(1,2-b)pyridazine | HCID 46835269 | 107.5% |
Reaction Steps
A solution of 4-bromo-6-chloropyridazin-3-amine (5.0 g, 24 mmol) and 2-chloroacetaldehyde (12 g, 75 mmol) in ethanol (100 mL) was heated at reflux for 15 h. The reaction mixture was concentrated and washed with acetone (75 mL) to give 104a as a yellow solid (6.0 g, 71%). MS: [M+H]+ 234.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722676B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-63b9588283e3404381ff57319d1b4003 |
| Source note | uspto-grants-2014_05 |