Sodium borohydride → HCID 86684141, compound

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Reaction Steps

To a solution of 114b (1.0 g, 3.0 mmol) in methanol (50 mL) was added sodium borohydride (380 mg, 9.0 mmol) at 10° C. and stirred for another 30 minutes. Then the reaction mixture was quenched with water (1 mL) and concentrated. The residue was dissolved in dichloromethane (50 mL) and washed with water (10 mL). The organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure to afford 114c as a yellow solid (900 mg, 90%). MS: [M+H]+ 332.

Provenance & Evidence