tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → (S)-tert-Butyl 4-(6-(6-Chloroimidazo[1,2-b]pyridazin-8-ylamino)pyridin-3-yl)-3-methylpiperazine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate	HCID 11737525	—
Reactant	8-Bromo-6-chloroimidazo(1,2-b)pyridazine	HCID 46835269	—
Reactant	HCID 86684119	HCID 86684119	—
Product	(S)-tert-Butyl 4-(6-(6-Chloroimidazo[1,2-b]pyridazin-8-ylamino)pyridin-3-yl)-3-methylpiperazine-1-carboxylate	HCID 86684144	80%

Reaction Steps

Following the procedure for 101b and starting with 8-bromo-6-chloroimidazo[1,2-b]pyridazine 104a (1.44 g, 6.2 mmol), and 115b (905 mg, 3.1 mmol) afforded 115c as a yellow solid (2.2 g, 80%). MS-ESI: [M+H]+ 444.2

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08722676B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-d4399297d51b4e369b15fc47ff22c76a
Source note	uspto-grants-2014_05