反应详情

温度

150 °C

An autoclave was charged with 115c (1.60 g, 3.6 mmol) and HBr/AcOH (60 mL). It was heated at 150° C. for 18 h. The reaction mixture was concentrated under reduced pressure to give black oil. The oil was recrystallized with methanol (30 mL)/dichloromethane (30 mL)/petroleum ether (90 mL) to afford 115d as a yellow solid (1.1 g, 65%). MS-ESI: [M+H]+ 388.1

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customto give black oil
3. customThe oil was recrystallized with methanol (30 mL)/dichloromethane (30 mL)/petroleum ether (90 mL)