反应详情

A 250-mL round-bottomed flask was purged with nitrogen and charged with 117d (1.5 g, 5.7 mmol), 10% palladium on carbon (50% wet, 750 mg), and ethanol (60 mL). The flask was evacuated, charged with hydrogen gas, and stirred at room temperature for 15 h. The hydrogen was then evacuated and nitrogen charged into the flask. The catalyst was removed by filtration through a pad of Celite and the filtrate was concentrated under reduced pressure to afford 117e (1.2 g, 90%), which was used in the next step without further purification. MS: [M+H]+ 234

1. customA 250-mL round-bottomed flask was purged with nitrogen
2. customThe flask was evacuated
3. additioncharged with hydrogen gas
4. customThe hydrogen was then evacuated
5. additionnitrogen charged into the flask
6. customThe catalyst was removed by filtration through a pad of Celite
7. concentrationthe filtrate was concentrated under reduced pressure