HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178475812, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Fluoro-2-(6-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenylamino)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-2-yl)-6-(1-oxo-3,4,6,7,8,9-hexahydropyrazino[1,2-a]indol-2(1H)-yl)benzyl Acetate | HCID 86684154 | — |
| Product | HCID 178475812 | HCID 178475812 | 30.1% |
Reaction Steps
A mixture of 117g (550 mg, 0.660 mmol) and CF3COOH (6 mL) was stirred at room temperature for 2 h. It was then concentrated under reduced pressure to afford crude 117h as a yellow solid (140 mg, 30%), which was used in the next step without further purification. MS-ESI: [M+H]+ 706.4
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722676B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-0e95fa5a1cb04aa29d360ee751f1587a |
| Source note | uspto-grants-2014_05 |