Trifluoroacetic acid → HCID 178475811, compound

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	{4-Fluoro-2-[6-({4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}amino)-9-{[2-(trimethylsilyl)ethoxy]methyl}purin-2-yl]-6-{6-oxo-8-thia-5-azatricyclo[7.4.0.02,7]trideca-1(9),2(7)-dien-5-yl}phenyl}methyl Acetate	HCID 86684157	—
Product	HCID 178475811	HCID 178475811	60%

Reaction Conditions

Temperature	30 °C

Reaction Steps

A mixture of 119a (307 mg, 0.360 mmol) and CF3COOH (5 mL) was stirred at 30° C. for 2 h. The mixture was evaporated in vacuo and the residue was diluted with water (5 mL). The pH of the mixture was adjusted to 7 with saturated NaHCO3 solution and extracted with ethyl acetate (3×10 mL). The combined extract was dried over MgSO4 and evaporated to dryness to afford 119b (150 mg, 60%), which was used in the next step without further purification. MS-ESI: [M+H]+ 723.4

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08722676B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-968fa35c1101420182763e7318800f66
Source note	uspto-grants-2014_05