8-Bromo-6-chloroimidazo(1,2-b)pyridazine → HCID 86684166, compound

HRID 1024102Notes

Reaction equation

HRID 1024102 reaction equation
Br[C:2]1[C:3]2[N:4]([CH:9]=[CH:10][N:11]=2)[N:5]=[C:6]([Cl:8])[CH:7]=1.[CH3:12][N:13]1[CH2:18][CH2:17][N:16]2[N:19]=[C:20]([NH2:22])[CH:21]=[C:15]2[CH2:14]1>>[Cl:8][C:6]1[CH:7]=[C:2]([NH:22][C:20]2[CH:21]=[C:15]3[CH2:14][N:13]([CH3:12])[CH2:18][CH2:17][N:16]3[N:19]=2)[C:3]2[N:4]([CH:9]=[CH:10][N:11]=2)[N:5]=1

Participants

3

Reactant 2

HCID 468352698-Bromo-6-chloroimidazo(1,2-b)pyridazineHCID 580439335-methyl-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-2-amine

Product 1

HCID 86684166HCID 86684166, compound

Procedure

Following the procedures as described in Example 104b, and starting with 8-bromo-6-chloroimidazo[1,2-b]pyridazine 104a, 1.43 g, 6.2 mmol) and 124e (900 mg, 5.9 mmol) afforded 124f was as a yellow solid (800 mg, 44%). MS-ESI: [M+H]+ 304.1

Sources & evidence

ORD record
ord-c886e416e83e4b60949fea5e2d02a1e8
Source dataset
uspto-grants-2014_05
Patent number
US08722676B2

Reaction notes

Loading…