HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylethanolamine → N,N-Diethyl-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]ethan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylethanolamine | HCID 7497 | — |
| Reactant | 3-(Diethylamino)-1-propanol | HCID 12159 | — |
| Reactant | N-Piperidinoethanol | HCID 18232 | — |
| Reactant | 2-Morpholinoethanol | HCID 61163 | — |
| Reactant | 1-Pyrrolidineethanol | HCID 76288 | — |
| Product | N,N-Diethyl-2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]ethan-1-amine | HCID 59593267 | — |
| Product | HCID 59593289 | HCID 59593289 | — |
| Product | HCID 59593291 | HCID 59593291 | — |
| Product | HCID 59774818 | HCID 59774818 | — |
Reaction Steps
Additional 5-substituted 7-azaindoles were prepared following the protocol of Scheme 31, replacing 4-morpholineethanol with either 2-diethylamino-ethanol, 3-diethylamino-propan-1-ol, 2-piperidin-1-yl-ethanol, or 2-pyrrolidin-1-yl-ethanol to provide diethyl-[2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-ethyl]-amine, Diethyl-[3-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-propyl]-amine, 5-(2-piperidin-1-yl-ethoxy)-1H-pyrrolo[2,3-b]pyridine, and 5-(2-pyrrolidin-1-yl-ethoxy)-1H-pyrrolo[2,3-b]pyridine, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722702B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-3c2c39e2d64e407d90848ac3f51be4c4 |
| Source note | uspto-grants-2014_05 |