HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-ethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester → 5-amino-2-ethyl-2H-pyrazole-3-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-ethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester | HCID 57619279 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-amino-2-ethyl-2H-pyrazole-3-carboxylic acid methyl ester | HCID 57619416 | — |
Reaction Steps
To 2-ethyl-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester (526, 1.30 g, 6.53 mmol) in methanol (60.0 mL) was added 20% Pd(OH)2/C (0.1 g). The reaction was stirred under an atmosphere of hydrogen overnight. The reaction was filtered and concentrated to give a light yellow solid (527, 1.0 g, 90.6%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722702B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-3a0b5701af584378be721001a0909dbc |
| Source note | uspto-grants-2014_05 |