4,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidine → 5-Methyl-pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide

HRID 10243Notes

Reaction equation

HRID 10243 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:9]([NH2:12])(=[O:11])=[O:10])=[N:6][CH:7]=1.[Cl:13][C:14]1[C:19]([O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[O:27][CH3:28])=[C:18](Cl)[N:17]=[C:16]([C:30]2[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=2)[N:15]=1>>[Cl:13][C:14]1[N:15]=[C:16]([C:30]2[CH:35]=[CH:34][N:33]=[CH:32][CH:31]=2)[N:17]=[C:18]([NH:12][S:9](=[O:11])(=[O:10])[NH:8][C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][N:6]=2)[C:19]=1[O:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[O:27][CH3:28]

Participants

3

Reactant 2

HCID 111754584,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidineHCID 21041312HCID 21041312, compound

Product 1

HCID 219795455-Methyl-pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amideYield 17%

Procedure

According to the procedure described in referential Example 1e), 5-methyl-pyridine-2-sulfamic acid amide (252 mg, Referential Example 20) was reacted with 4,6-dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (410 mg, Referential Example 1d)) to give 5-methyl-pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide (100 mg). tR=4.02 min (LC); [M+H]+=499.33 (ES+);

Sources & evidence

ORD record
ord-e9f16d4033b3426ca548f02ccc0c2b35
Source dataset
uspto-grants-2006_08
Patent number
US07094781B2

Reaction notes

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