Ether hydrochloride → HCID 86718836, compound

Participants

Reaction Steps

To the solution of crude (3) (220 gram, 92.2% HPLC purity) in ethyl ether (450 milliliter), was added saturated hydrochloric acid/ethyl ether solution dropwise at room temperature over 30 minutes. The precipitated solid was filtered, the filter cake was washed with mixed solvent (ethyl ether: n-hexane 1:1 v/v; 400 mL), and dried under high vacuum for 2 hours at room temperature to give the desired product (14) (160 g; yield: 62.4%) as a light tan solid. HPLC purity: 98%; LC-MS: m/z 222 (MH+);

Provenance & Evidence