2-Nitrobenzoyl chloride → HCID 86718834, compound

Participants

Reaction Conditions

Reaction Steps

The above solution of (trimethylsilyl)ethynyl)zinc(II) chloride (16) in THF was warmed to 0° C., and added to the mixture of 2-nitrobenzoyl chloride (0.94 g) and tetrakis(triphenylphosphine) palladium(0) (176 mg) in tetrahydrofuran at 0° C. under a N2 atmosphere. The reaction mixture was maintained at 0° C. for 30 minutes. Aqueous ammonium chloride solution was added to quench the reaction. It was then extracted 3-times with EtOAc (3×100 mL), dried over sodium sulfate, filtered and concentrated under vacuum. The residue was purified by preparative TLC to give 300 mg of the desired product (11).

Provenance & Evidence