HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1024354Generated: October 25, 2026
Sodium Hydroxide → 3-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazole
https://huagongshe.com/reaction/1024354
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1-Propanone, 1-(4-chlorophenyl)-3-(dimethylamino)-, hydrochloride (1:1) | HCID 200370 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazole | HCID 13143700 | — |
Reaction Steps
Under N2 atmosphere, 1-(4-chloro-phenyl)-3-dimethylamino-propan-1-one hydrochloride (37.2 g) was dissolved in warm MeOH (75 mL), and slowly added to a solution of hydrazine hydrate (23 mL) and 50% aqueous NaOH (12 mL) in MeOH (30 mL) stirred at 50° C. The mixture was refluxed for 2 hours, and evaporated under reduced pressure. Water was added to the residue, followed by extraction with DCM. The organic phase was washed twice with water, dried and evaporated under reduced pressure, to give 25.0 g of a yellow solid, m.p. 90-100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08722887B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-92c5b61e2c3a4d50b6f5137860c46781 |
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| Source note | uspto-grants-2014_05 |
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