Hydrochloric Acid → HCID 46223480, compound

Participants

Reaction Steps

A solution of EXAMPLE 5B (44 mg, 0.077 mL) in tetrahydrofuran (2 mL) was treated with 2N HCl (1 mL), then stirred at room temperature for 18 hours. The resulting suspension was filtered and the solid was collected and dried to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.72 (s, 3H) 3.32-3.45 (m, 4H) 3.84-3.91 (m, 1H) 4.12 (dd, J=13.90, 7.80 Hz, 1H) 4.34 (dd, J=13.90, 3.73 Hz, 1H) 6.89 (d, J=9.15 Hz, 2H) 6.89-6.93 (m, 2H) 7.38 (d, J=9.15 Hz, 2H) 7.45 (d, J=8.81 Hz, 2H) 7.65 (d, J=8.81 Hz, 2H) 7.94 (s, 1H) 7.99 (d, J=0.68 Hz, 1H) 8.06 (s, 1H) 8.28 (d, J=0.68 Hz, 1H) 8.72 (s, 1H) 9.05 (s, 1H); MS (ESI(+)) m/z 531.2 (M+H)+.

Provenance & Evidence