1-Bromo-3-methylbutane → 4-Bromo-1-isopentylpyridin-2(1H)-one

HRID 1024385Notes

Reaction equation

HRID 1024385 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[CH:3]=1.O[C:14]1C=CN(CCC(C)C)C(=O)C=1.C(N1C=CC(O)=CC1=O)CCC.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1.BrCCC(C)C>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][CH2:9][CH:10]([CH3:14])[CH3:11])[C:4](=[O:12])[CH:3]=1

Participants

6

Reactant 5

HCID 78911-Bromo-3-methylbutaneHCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 594970761-butyl-4-hydroxy-1H-pyridine-2-oneHCID 594970924-bromo-1-butylpyridin-2(1H)-oneHCID 668856654-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one

Product 1

HCID 594970904-Bromo-1-isopentylpyridin-2(1H)-one

Procedure

Intermediate D4 was prepared following the same procedure implemented for the synthesis of D3, using 4-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one as starting material, which was prepared by the same method used for the synthesis of intermediate D2, by reaction of 4-benzyloxy-1H-pyridin-2-one with 1-bromo-3-methylbutane.

Workup

  1. customwas prepared by the same method

Sources & evidence

ORD record
ord-96ac8770619c4d79aeac8dede004c906
Source dataset
uspto-grants-2014_05
Patent number
US08722894B2

Reaction notes

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