p-Toluenesulfonic acid → HCID 25221316, compound

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Reaction Steps

A mixture of compound E2 (0.10 g, 0.22 mmol) and a catalytic amount of p-toluenesulfonic acid in methanol (10 ml) was stirred at room temperature for 1 hour. The solvent was evaporated in vacuo and the resulting residue was taken up with DCM, washed with an aqueous saturated solution of NaHCO3, the combined organic extracts were dried (Na2SO4) and the solvent was evaporated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-30% EtOAc/DCM as eluent). The desired fractions were collected and evaporated in vacuo to yield E3 (0.05 g, 61%) as a colourless oil. Compounds E4 to E9 (Table 1) were prepared in a similar manner. Physico-Chemical Data LCMS—General Procedure

Provenance & Evidence