4,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidine → Pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide

HRID 10244Notes

Reaction equation

HRID 10244 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][S:8]([NH2:11])(=[O:10])=[O:9].[Cl:12][C:13]1[C:18]([O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:26][CH3:27])=[C:17](Cl)[N:16]=[C:15]([C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[N:14]=1>>[Cl:12][C:13]1[N:14]=[C:15]([C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[N:16]=[C:17]([NH:11][S:8](=[O:10])(=[O:9])[NH:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:18]=1[O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 111754584,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidineHCID 21041239Pyridine-2sulfamic acid amide

Product 1

HCID 21979539Pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amideYield 71.8%

Procedure

According to the procedure described in referential Example 1e), pyridine-2-sulfamic acid amide (60 mg, Referential Example 21) was reacted with 4,6-dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (100 mg, Referential Example 1d)) to give pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide (100 mg). tR=3.83 min (LC); [M−H]+=483.33 (ES−);

Sources & evidence

ORD record
ord-3a2f19201fb4458e938ba790074c31b8
Source dataset
uspto-grants-2006_08
Patent number
US07094781B2

Reaction notes

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