HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → 1H-Indazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1H-Pyrrolo[2,3-B]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]- | HCID 49759018 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Copper | HCID 23978 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1H-Indazole-5-carbonitrile | HCID 11126384 | — |
Reaction Steps
Compound 19 can be cyanated with, for example, KCN in heating DMF in the presence of a catalyst such as, copper or palladium to provide the 5-cyano azaindole 46.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722889B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-dcc98bf9435e4e029c865f2fca5b2c9c |
| Source note | uspto-grants-2014_05 |