Boron tribromide → HCID 178424876, compound

Participants

Reaction Conditions

Reaction Steps

4.3 1.24 g of “4b” are dissolved in 12 ml of dichloromethane under argon and cooled to 0° C. 3.45 ml of boron tribromide are added dropwise, and the mixture is stirred at room temperature for a further 16 hours. The mixture is subjected to conventional work-up, and the residue is, for further purification, chromatographed over a 120 g RP18 silica-gel column, giving 578 mg of 5-bromo-6-hydroxy-3-(3-methylbenzyl)-1H-indazole (“4c”).

Provenance & Evidence