Chlorophenyl isocyanate → Methyl 2-(5-(4-(3-(2-chlorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

참여 물질

역할	이름	HCID	투입량
반응물	Chlorophenyl isocyanate	HCID 76833	—
반응물	Methyl 2-(5-(4-aminophenyl)oxazole-2-carboxamido)-3-methylbutanoate	HCID 67150345	—
생성물	Methyl 2-(5-(4-(3-(2-chlorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate	HCID 52934130	79%

반응 단계

The title compound was synthesized analogous to Example 1, using 1-chloro-2-isocyanatobenzene and intermediate 1. Yield: 79%; 1HNMR (DMSO-d6, 300 MHz): δ 9.68 (s, 1H), 8.98 (d, 1H), 8.39 (s, 1H), 8.15 (dd, 1H), 7.82 (s, 1H), 7.78 (d, 2H), 7.63 (d, 2H), 7.48 (dd, 1H), 7.34 (m, 1H), 7.05 (m, 1H), 4.3, (m, 1H), 3.68 (s, 3H), 2.26 (m, 1H), 0.95 (d, 6H); MS (ES+) m/z 471 (M+1).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08722901B2
출처 데이터셋	uspto-grants-2014_05
ORD ID	ord-ea24c936800047828ec1c13d4156b0e9
출처 메모	uspto-grants-2014_05