2,3-dihydro-1H-indene-2-carbonyl chloride → Methyl 2-(5-(4-(2,3-dihydro-1H-indene-2-carboxamido)phenyl)thiazole-2-carboxamido)-3-methylbutanoate

Participants

Reaction Steps

The title compound was synthesized analogous to Example 27, using 2,3-dihydro-1H-indene-2-carbonyl chloride and intermediate 2. Yield: 18%; 1H NMR (DMSO-d6, 300 MHz): δ 10.28 (s, 1H), 8.75 (d, 1H), 8.37 (s, 1H), 7.75 (s, 4H), 7.25 (m, 2H), 7.16 (m, 2H), 4.35 (t, 1H), 3.68 (s, 3H), 3.43 (m, 1H), 3.19 (d, 4H), 2.28 (m, 1H), 0.96 (t, 6H); MS (ESI) m/z 487.0 [M+H]+.

Provenance & Evidence