5-Indanyl isocyanate → (S)-methyl 2-(5-(4-(3-(2,3-dihydro-1H-inden-5-yl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Participants

Reaction Steps

The title compound was synthesized analogous to Example 1, using 5-isocyanato-2,3-dihydro-1H-indene (84.87 mg, 0.533 mmol) and intermediate 1. Yield: 92%; 1H NMR (DMSO-d6, 300 MHz): δ 9.005-8.978 (d, 1H), 8.912 (s, 1H), 8.624 (s, 1H), 7.804 (s, 1H), 7.781-7.752 (d, J=8.7 Hz, 2H), 7.617-7.587 (d, J=9 Hz, 2H), 7.395 (s, 1H), 7.172-7.106 (m, 2H), 4.328-4.277 (m, 1H), 3.681 (s, 3H), 2.860-2.772 (m, 4H), 2.286-2.217 (m, 1H), 2.052-2.154 (m, 2H), 0.980-0.928 (d, J=6.9 Hz, 6H); MS (ESI) m/z 475 [M−H], 477 [M+H]+.

Provenance & Evidence