4-Chlorophenyl Isocyanate → (S)-Methyl 2-(5-(4-(3-(4-chlorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

Beteiligte Stoffe

Reaktionsschritte

The title compound was synthesized analogous to Example 1, using 1-chloro-4-isocyanatobenzene (0.533 mmol) and intermediate 1. 1H NMR (DMSO-d6, 300 MHz): δ 9.011-8.983 (d, 2H), 8.919 (s, 1H), 7.813 (s, 1H), 7.792-7.763 (d, J=8.7 Hz, 2H), 7.624-7.595 (d, J=8.7 Hz, 2H), 7.518-7.488 (d, J=9 Hz, 2H), 7.357-7.327 (d, J=9 Hz, 2H), 4.327-4.276 (m, 1H), 3.680 (s, 3H), 2.285-2.216 (m, 1H), 0.979-0.957 (d, J=6.6 Hz, 6H); MS (ESI) m/z 471 (M+H)+.

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