Benzene, 1-chloro-3-isocyanato- → (S)-methyl 2-(5-(4-(3-(3-chlorophenyl)ureido)phenyl)oxazole-2-carboxamido)-3-methylbutanoate

関与物質

反応手順

The title compound was synthesized analogous to Example 1, using 1-chloro-3-isocyanatobenzene (0.533 mmol) and intermediate 1. 1H NMR (DMSO-d6, 300 MHz): δ 9.056 (s, 1H), 9.013-8.986 (d, 2H), 7.820 (s, 1H), 7.799-7.770 (d, J=8.7 Hz, 2H), 7.728-7.704 (m, 1H), 7.631-7.601 (d, J=9 Hz, 2H), 7.347-7.268 (m, 2H), 7.059-7.024 (m, 1H), 4.328-4.277 (m, 1H), 3.680 (s, 3H), 2.286-2.218 (m, 1H), 0.980-0.958 (d, J=6.6 Hz, 6H); MS (ESI) m/z 469 (M−H), 470 (M+H)+.

情報源と証拠