4,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidine → Pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide

HRID 10245Notes

Reaction equation

HRID 10245 reaction equation
[CH2:1]([NH:3][S:4](=[O:7])(=[O:6])[NH2:5])[CH3:2].Cl[C:9]1[C:14]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[O:22][CH3:23])=[C:13]([Cl:24])[N:12]=[C:11]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)[N:10]=1>>[Cl:24][C:13]1[N:12]=[C:11]([C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)[N:10]=[C:9]([NH:5][S:4](=[O:7])(=[O:6])[NH:3][C:1]2[CH:2]=[CH:13][CH:14]=[CH:9][N:10]=2)[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[O:22][CH3:23]

Participants

3

Reactant 2

HCID 111754584,6-Dichloro-5-(2-methoxyphenoxy)-2-(pyridin-4-YL)pyrimidineHCID 21263690(Ethylsulfamoyl)amine

Product 1

HCID 21979539Pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amideYield 100.5%

Procedure

According to the procedure described in referential Example 1e), ethyl-sulfamic acid amide (40 mg, Referential Example 22) was reacted with 4,6-dichloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (100 mg, Referential Example 1d)) to give pyridine-2-sulfamic acid-[6-chloro-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-amide (70 mg). tR=4.40 min (LC); [M−H]+=434.28 (ES−);

Sources & evidence

ORD record
ord-9ec8837a87b248b2b9999eaadda6b40a
Source dataset
uspto-grants-2006_08
Patent number
US07094781B2

Reaction notes

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