Hydrochloric Acid → HCID 68194317, compound

Participants

Reaction Conditions

Reaction Steps

To a suitable reactor was added crude 3b in EtOH (100 mL) solution at 20-30° C. under N2. The mixture was cooled to −25 to −15° C., and NaBH4 (0.77 g) in H2O (7.7 mL) was added at below −8° C. The reaction mixture was warmed to −10 to −5° C. and stirred for 2 hr. The reaction was deemed completed as determined by TLC. 1N HCl aqueous solution (20 mL) was added at below 10° C. The mixture was extracted with EtOAc (100 mL×2). The separated organic portions were combined and concentrated under at 40-50° C. reduced pressure to afford crude 4b. The diastereomeric ratio of crude 4b was determined to be 97/3 by HPLC analysis.

Provenance & Evidence