反应详情

温度

150 °C

A mixture of 4-bromo-N-(4-chloro-phenyl)-benzamide (1.14 g, 3.67 mmol) in SOCl2 (4.5 mL) is heated to 80° C. for 2 h before SOCl2 is removed in vacuo. The resulted imidoyl chloride intermediate is dissolved in anhydrous dichloroethane (18 mL) and transferred into a sealed tube. After adding 5-amino-3-methylsulfanyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester (1.12 g, 4.04 mmol) and TiCl4 (0.80 mL, 7.3 mmol), the reaction tube is sealed and heated at 150° C. overnight. After cooling down to room temperature the reaction mixture is poured into water (200 mL) and extracted with chloroform (3×100 mL). The organic layers are combined, washed with brine, dried over MgSO4, concentrated, and purified by silica gel chromatography to provide 6-(4-bromo-phenyl)-5-(4-chloro-phenyl)-3-methylsulfanyl-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one as a white solid product; HPLC-MS calculated for C24H16BrClN4OS (M+H+) 523.0, found 523.0.

1. customis removed in vacuo
2. dissolutionThe resulted imidoyl chloride intermediate is dissolved in anhydrous dichloroethane (18 mL)
3. customtransferred into a sealed tube
4. customthe reaction tube is sealed
5. temperatureAfter cooling down to room temperature the reaction mixture
6. extractionextracted with chloroform (3×100 mL)
7. washwashed with brine
8. dry with materialdried over MgSO4
9. concentrationconcentrated
10. custompurified by silica gel chromatography