反应详情

To a solution of 5-(4-chloro-phenyl)-6-(4-methanesulfinyl-phenyl)-1-phenyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one (1.20 g, 2.60 mmol) in dry acetic anhydride (12 mL) sodium acetate (0.800 g, 9.76 mmol) is added and the resulting mixture is heated to reflux. After 5 h, the reaction mixture is concentrated. The crude product is purified by column chromatography (silica gel, 60-120 mesh) to afford (4-(5-(4-chlorophenyl)-4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenylthio)methyl acetate.

1. temperaturethe resulting mixture is heated to reflux
2. concentrationthe reaction mixture is concentrated
3. customThe crude product is purified by column chromatography (silica gel, 60-120 mesh)